If you become pregnant while using this medication, contact your doctor immediately. Breast-feeding: Corticosteroids such as desoximetasone may pass into breast milk. If you are a breast-feeding mother and are using this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: Children may be more susceptible to the side effects that can occur when applying large amounts of this medication to the skin for long periods of time. These side effects include slowing of growth and delayed weight gain, especially if large amounts of this medication are used for long periods of time. Children should use the smallest amount of desoximetasone that will be effective for the shortest period of time possible.
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:. An interaction between two medications does not always mean that you must stop taking one of them.
Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter non-prescription , and herbal medications you are taking.
Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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Source: www. About this Medication. How does this medication work? What will it do for me? Sponsored Health Tool. Dry and itchy skin. Learn more. When it comes to eczema, you should know what's available. Acne Doctor Discussion Guide. Acne: Fact vs Myth Quiz. Acne Treatment Options Table. Geriatric patients may be more likely to have preexisting skin atrophy secondary to aging.
Purpura and skin lacerations that may raise the skin and subcutaneous tissue from deep fascia may be more likely to occur with the use of topical corticosteroids in geriatric patients. Use of lower potency topical corticosteroids also may be necessary in some patients. The normal inflammatory response to local infections can be masked by desoximetasone. Application of topical corticosteroids to areas of infection, including tuberculosis of the skin, dermatologic fungal infection, and cutaneous or systemic viral infection e.
If the infection does not respond to the antimicrobial therapy, the concurrent use of the topical corticosteroid should be discontinued until the infection is controlled. Topical corticosteroids may delay the healing of non-infected wounds, such as venous stasis ulcers. Potent topical corticosteroids should not be used to treat acne vulgaris, acne rosacea, or perioral dermatitis.
Desoximetasone may aggravate these conditions. Topical corticosteroids such as desoximetasone should be used with caution in patients with diabetes mellitus. Exacerbation of diabetes may occur with systemic absorption of the topical corticosteroid.
Use of topical corticosteroids may further delay healing of skin ulcers in diabetic patients. Metyrapone: Major Medications which affect pituitary or adrenocortical function, including all corticosteroid therapy, should be discontinued prior to and during testing with metyrapone. Patients taking inadvertent doses of corticosteroids on the test day may exhibit abnormally high basal plasma cortisol levels and a decreased response to the test.
Although systemic absorption of topical corticosteroids is minimal, temporary discontinuation of these products should be considered if possible to reduce the potential for interference with the test results. Topical corticosteroids exhibit anti-inflammatory, antipruritic, and vasoconstrictive properties. At the cellular level, corticosteroids induce peptides called lipocortins.
Lipocortins antagonize phospholipase A2, an enzyme which causes the breakdown of leukocyte lysosomal membranes to release arachidonic acid. This action decreases the subsequent formation and release of endogenous inflammatory mediators including prostaglandins, kinins, histamine, liposomal enzymes and the complement system. Early anti-inflammatory effects of topical corticosteroids include the inhibition of macrophage and leukocyte movement and activity in the inflamed area by reversing vascular dilation and permeability.
Later inflammatory processes such as capillary production, collagen deposition, keloid scar formation also are inhibited by corticosteroids. Clinically, these actions correspond to decreased edema, erythema, pruritus, plaque formation and scaling of the affected skin.
Desoximetasone is administered topically as a cream, ointment, and gel. Desoximetasone is metabolized in the liver and undergoes conjugation to form the glucuronide and sulfate ester. Desoximetasone and its metabolites are primarily excreted by the kidneys and to a lesser extent by the bile. The half-life of desoximetasone is about 15—17 hours. Desoximetasone is absorbed from normal intact skin.
Absorption of desoximetasone is dependent on many factors, including the vehicle, the integrity of the epidermis, and the use of occlusive dressings.
Percutaneous absorption is increased by the use of occlusive dressings, which may be useful for treating resistant dermatoses. Absorption of topical corticosteroids is increased in areas that have skin damage, inflammation, or in areas where the stratum corneum is thin such as the eyelids, genitalia, axillae, and face.
Pharmacokinetic studies following application of desoximetasone cream 0. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Generic alternatives may be available. Desoximetasone Topical pronounced as des ox i met' a sone. Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?
What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names Other names. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. Other uses for this medicine. What special precautions should I follow?
Before using desoximetasone topical, tell your doctor and pharmacist if you are allergic to desoximetasone, any other medications, or any of the ingredients in desoximetasone topical products. Ask your pharmacist for a list of the ingredients. Be sure to mention the following: other corticosteroid medications and other topical medications tell your doctor if you have an infection or any other skin problems or have or ever had diabetes,, Cushing's syndrome an abnormal condition that is caused by excess hormones [corticosteroids] ,, or liver problems.
If you become pregnant while using desoximetasone, call your doctor. Unless your doctor tells you otherwise, continue your normal diet. Desoximetasone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: burning, itching, irritation, redness, or dryness of the skin tiny red bumps or rash around the mouth unwanted hair growth acne small white or red bumps on the skin bruising or shiny skin red or purple blotches or lines under the skin thin, fragile, or dry skin changes in skin color Some side effects can be serious.
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